Nano-Bio Engineering Group
Shamloo, Associate Professor
Engineering Department, Sharif University of Technology
Ph.D, Stanford University
University of California, Berkeley
and Application of Microfluidics Devices
Design and Fabrication of Nano-Mechanical Structures
Engineering and Biomaterials-Stem Cell Interactions
Analysis of Biological Systems and Cell Mechanics
Element Modeling of Elasto-Plastic Materials
Shamloo A., Forouzandehmehr M.,
deposition maps for micro-and nanoparticles targeting an atherosclerotic
plaque: attributions to the receptor-mediated adsorption on the inflamed
endothelial cells, Biomechanics and modeling in mechanobiology, In print.
A., Ghazimirsaeed E., Shamloo
A. (2019) Numerical simulation of mixing
and heat transfer in an
integrated centrifugal microfluidic system for nested-PCR amplification and
gene detection, Sensors
Actuators B: Chemical, Accepted.
S., Shamloo, A., (2018) Bilayered heparinized
vascular graft fabricated by combining electrospinning and freeze drying
methods, Materials Science and Engineering C, Accepted.
H., Shamloo, A., Hannani, S.K., (2018) Exergy analysis
of parabolic trough solar collectors using Al2O3/synthetic oil nanofluid, Solar Energy, 173,
P., Shamloo, A., (2018) Parametric study
on mixing process in an in-plane spiral micromixer
utilizing chaotic advection, Analytica
Chimica Acta, 1022,
A., Asadbegi, M., Khandan,
V., Amanzadi, A., (2018) Designing a new
for metal chelation and Aβ inhibition, Archives of
biochemistry and biophysics, In print.
A., Ahmad, S., Momeni, M., (2018) Design and
parameter study of integrated microfluidic platform for CTC isolation and enquiry;
A numerical approach, Biosensors, 8, 56.
S.A., Farahmand, F., Shamloo, A., (2018) A
three-dimensional micromechanical model of brain white matter with
histology-informed probabilistic distribution of axonal fibers, Journal of the
mechanical behavior of biomedical materials, In print.
A., (2018) Molecular Dynamics Simulation of PASylated
G-CSF and Proposing a Modified PAS String Sequence in order to Improve
Drug’s Properties, Iranian Journal of Biomedical Engineering, 4, 303-311.
A., Shamloo, A., (2018) Dynamics of a
magnetically rotated micro swimmer inspired by paramecium metachronal wave, Progress in
biophysics and molecular biology, In print.
B., Shamloo, A., (2018) Mechanical
differences between ATP and ADP actin states: A molecular dynamics study, Journal of
theoretical biology, 448, 94-103.
F., Masoudi, M.M., Shamloo,
A., Habibi-Rezaei, M., (2018) Modeling,
simulation, and employing dilution–dialysis microfluidic chip (DDMC) for
heightening proteins refolding efficiency, Bioprocess and biosystems engineering, 1-8.
S.A., Shamloo, A., Farahmand, F., (2018) Micromechanics of
brain white matter tissue: A fiber-reinforced hyperelastic
model using embedded element technique, Journal
of the mechanical behavior of biomedical materials, 80, 194-202.
A., Sarmadi, M., Aghababaie,
Z., Vossoughi, M., (2018) Accelerated
via sustained bFGF delivery based on a
PVA/chitosan/gelatin hydrogel incorporating PCL
journal of pharmaceutics, 537, 278-289.
A., Mashhadian, A., (2018) Inertial particle
focusing in serpentine channels on a centrifugal
platform, Physics of Fluids 30
F., Kokkinis, G., Bernardi,
J., Zand, M.R., Shamloo,
A., Giouroudi I. (2018). A novel
microfluidic platform for on-chip separation of 3 types of silica coated
SiO2), Sensors and Actuators
A: Physical, 270, 223-230.
A., Boodaghi, M. (2017). Design
and simulation of a microfluidic device for acoustic cell
Ultrasonics 84, 234-243.
A, Mehrafrooz, B. (2017) Nanomechanics of actin filament: A molecular dynamics
Cytoskeleton, In print.
M, Shamloo, A. (2017) Newtonian
and generalized Newtonian reacting flows in serpentine
pressure driven and centrifugal microfluidics,
Journal of Non-Newtonian Fluid
Mechanics, In print.
Forouzandehmehr, M., & Shamloo,
A. (2017). Margination and adhesion of micro-and nanoparticles in the
coronary circulation: a step towards optimised
drug carrier design. Biomechanics and Modeling in Mechanobiology,
Madadelahi, M., & Shamloo,
A. (2017). Droplet-based flows in serpentine microchannels:
Chemical reactions and secondary flows. International Journal of Multiphase
Flow, 97, 186-196.
Shamloo, A., & Kamali, A. (2017).
Numerical analysis of a Dielectrophoresis
field‐flow fractionation device for the separation of multiple cell
types. Journal of Separation Science.
Gilani, A., Koohsorkhi,
J., & Shamloo, A. (2017). Novel
method for cell penetration based on MEMS technology with failure and
impacting characterization of mouse ooctye membrane.
Sensors and Actuators A: Physical, 263, 461-470.
H., Nikbin, E., Shamloo,
A. (2017). Molecular dynamics
simulation of the
dissociation mechanism of P-selectin from PSGL-1.
Journal of Theoretical and
Khakrah, H., Shamloo,
A., & Hannani, S. K. (2017).
Determination of Parabolic Trough Solar Collector Efficiency Using Nanofluid: A Comprehensive Numerical Study. Journal of
Solar Energy Engineering, 139(5), 051006.
Shamloo, A., Madadelahi, M., & Abdorahimzadeh, S. (2017). Three-dimensional numerical
simulation of a novel electroosmotic micromixer.
Chemical Engineering and Processing: Process Intensification.
Shamloo, A., Nejad, M. A., & Saeedi, M. (2017). Fluid–structure interaction
simulation of a cerebral aneurysm: Effects of endovascular coiling
treatment and aneurysm wall thickening. Journal of the Mechanical Behavior
of Biomedical Materials, 74, 72-83.
Asadzade, M., & Shamloo,
A. (2017). Design and simulation of a novel bipolar plate based on
lung‐shaped bio‐inspired flow pattern for PEM fuel cell.
International Journal of Energy Research.
Shamloo, A., Vatankhah, P., &
Akbari, A. (2017). Analyzing mixing quality in a curved centrifugal micromixer through numerical simulation. Chemical
Engineering and Processing: Process Intensification, 116, 9-16.
Moradi, M., Shamloo,
A., Asadbegi, M., & Dezfuli,
A. D. (2017). Three dimensional pressure transient behavior study in stress
sensitive reservoirs. Journal of Petroleum Science and Engineering, 152,
Sarmadi, M., Shamloo,
A., & Mohseni, M. (2017). Utilization of
Molecular Dynamics Simulation Coupled with Experimental Assays to Optimize
Biocompatibility of an Electrospun PCL/PVA
Scaffold. PloS one, 12(1), e0169451.
A., A. Selahi, and
M. Madadelahi, Designing and modeling a centrifugal microfluidic device to
separate target blood cells. Journal of Micromechanics and Microengineering, 2016. 26(3): p. 035017.
and M. Sarmadi, Investigation of the adhesive
characteristics of polymer–protein systems through molecular dynamics
simulation and their relation to cell adhesion and proliferation.
Integrative Biology, 2016. 8(12): p. 1276-1295.
P. Vatankhah, and M.A. Bijarchi,
Numerical optimization and inverse study of a microfluidic device for blood
plasma separation. European Journal of Mechanics-B/Fluids, 2016. 57: p.
et al., Computing the blood brain barrier (BBB) diffusion coefficient: A
molecular dynamics approach. Journal of Magnetism and Magnetic Materials,
2016. 410: p. 187-197.
et al., A comparative study of collagen matrix density effect on
endothelial sprout formation using experimental and computational
approaches. Annals of biomedical engineering, 2016. 44(4): p. 929-941.
M. Mirzakhanloo, and M.R. Dabirzadeh,
Numerical Simulation for efficient mixing of Newtonian and non-Newtonian
fluids in an electro-Osmotic Micro-Mixer. Chemical Engineering and
Processing: Process Intensification, 2016.
A. Merdasi, and P. Vatankhah,
Numerical Simulation of Heat Transfer in Mixed Electroosmotic Pressure-Driven
Flow in Straight Microchannels. Journal of Thermal Science and Engineering
Applications, 2016. 8(2): p. 021011.
M. Madadelahi, and A. Akbari, Numerical simulation of centrifugal
serpentine micromixers and analyzing mixing quality parameters. Chemical
Engineering and Processing: Process Intensification, 2016. 104: p. 243-252.
A.N., A. Shamloo, and M.T. Ahmadian, Simulation of Paramecium Chemotaxis Exposed to
Calcium Gradients. Cell biochemistry and biophysics, 2016: p. 1-12.
M., A. Shamloo, and A.D. Dezfuli, A sequential implicit discrete fracture model
for three-dimensional coupled flow-geomechanics
problems in naturally fractured porous media. Journal of Petroleum Science
and Engineering, 2016.
M.Z., A. Shamloo, et al., Dynamic Analysis of Magnetic Nanoparticles
Crossing Cell Membrane. Journal of Magnetism and Magnetic Materials, 2016.
M.Z., A. Shamloo, et al., Optimal Magnetic Field for Crossing
Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A
Computational Approach. Biosensors, 2016. 6(2): p. 25.
A., A. Shamloo, et al., A computational model for estimation of
mechanical parameters in chemotactic endothelial cells. Scientia
Iranica. Transaction B, Mechanical Engineering,
2016. 23(1): p. 260.
H. and A. Shamloo, The effect of rippled graphene sheet roughness on
the adhesive characteristics of a collagen–graphene system. International
Journal of Adhesion and Adhesives, 2016. 64: p. 9-14.
M., A. Shamloo, et al., Antimicrobial Wound Dressing Containing
Silver Sulfadiazine With High Biocompatibility: In Vitro Study. Artificial
E., A. Shamloo, et al., Dual improvement of DNA-directed antibody
immobilization utilizing magnetic fishing and a polyamine coated surface.
RSC Advances, 2016. 6(112): p. 111210-111216.
A., A. Shamloo, et al., High throughput blood plasma separation
using a passive PMMA microfluidic device. Microsystem Technologies, 2015:
et al., Performance optimization of microreactors
by implementing geometrical and fluid flow control in the presence of
electric field: a computational study. Microsystem Technologies, 2015.
21(6): p. 1275-1285.
N. Mohammadaliha, and M. Mohseni,
Integrative utilization of microenvironments, biomaterials and
computational techniques for advanced tissue engineering. Journal of
biotechnology, 2015. 212: p. 71-89.
A. Golgoon, and E.G. Zadeh.
Role of α and β Transmembrane Domains in Integrin Clustering. in Actuators. 2015. Multidisciplinary Digital Publishing
F. Manuchehrfar, and H. Rafii-Tabar,
A viscoelastic model for axonal microtubule rupture. Journal of
biomechanics, 2015. 48(7): p. 1241-1247.
and L. Amirifar, A microfluidic device for 2D to
3D and 3D to 3D cell navigation. Journal of Micromechanics and Microengineering, 2015. 26(1): p. 015003.
M. Heibatollahi, and M.R. Mofrad,
Directional migration and differentiation of neural stem cells within
three-dimensional microenvironments. Integrative Biology, 2015. 7(3): p.
M.Z., A. Shamloo, et al. Superparamagnetic Nanoparticles for
Epilepsy Detection. in World Congress on Medical
Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada. 2015.
M. and A. Shamloo, A model for cell density effect on stress fiber
alignment and collective directional migration. Physical biology, 2015.
12(6): p. 066023.
M.Z., A. Shamloo, et al., Toward Epileptic Brain Region Detection
Based on Magnetic Nanoparticle Patterning. Sensors, 2015. 15(9): p.
et al. Homo-oligomerization of transmembrane α-domain of integrin. in 2014 36th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society. 2014. IEEE.
Cell‐cell interactions mediate cytoskeleton organization and
collective endothelial cell chemotaxis. Cytoskeleton, 2014. 71(9): p.
et al., Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging
of murine mast cells in microfluidic gradient chambers. Integrative
Biology, 2013. 5(8): p. 1076-1085.
M. Heibatollahi, and E. Ghafar-Zadeh.
Parallel in-vitro and in-vivo techniques for optimizing cellular
microenvironments by implementing biochemical, biomechanical and
electromagnetic stimulations. in 2012 Annual
International Conference of the IEEE Engineering in Medicine and Biology
Society. 2012. IEEE.
H. Xu, and S. Heilshorn, Mechanisms of vascular
endothelial growth factor-induced pathfinding by endothelial sprouts in
biomaterials. Tissue Engineering Part A, 2011. 18(3-4): p. 320-330.
et al., Novel Receptor-Mediated Endothelial Cell Chemotaxis. Biophysical
Journal, 2010. 98(3): p. 497a.
and S.C. Heilshorn, Matrix density mediates
polarization and lumen formation of endothelial sprouts in VEGF gradients.
Lab on a Chip, 2010. 10(22): p. 3061-3068.
and S.C. Heilshorn. The Interplay Between
Biomechanical and Biochemical Factors Regulates Lumen Formation and
Navigation of Endothelial Cell Sprouts. in ASME
2010 Summer Bioengineering Conference. 2010. American Society of Mechanical
Shamloo, A. and
S.C. Heilshorn, Matrix Rigidity Mediates Growth
Factor Response during 3D Endothelial Cell Sprouting. Biophysical Journal,
2010. 98(3): p. 730a.
Kuhnert, F., A.
Shamloo, et al., Essential regulation of CNS angiogenesis by the orphan
G protein–coupled receptor GPR124. Science, 2010. 330(6006): p. 985-989.
et al., Endothelial cell polarization and chemotaxis in a microfluidic
device. Lab on a chip, 2008. 8(8): p. 1292-1299.
M. Abeddoust, and N. Mehboudi,
MICROFLUIDIC DEVICES AS IN VITRO MICROENVIRONMENTS FOR-STEM CELL CULTURE.
M., A. Shamloo, et al., PLAQUE STRUCTURE AFFECTS MECHANICAL STRESS
DISTRIBUTION WITHIN BLOOD VESSELS.
A., A. Shamloo, and A. Azami, Extended
finite element method in plasticity forming of powder compaction with
contact friction. International Journal of Solids and Structures, 2006.
43(18): p. 5421-5448.
A., A. Shamloo, et al., The extended finite element method (X-FEM)
for powder forming problems. Journal of materials processing technology,
2006. 177(1): p. 53-57.
A. Azami, and A. Khoei,
Modeling of pressure-sensitive materials using a cap plasticity theory in
extended finite element method. Journal of materials processing technology,
2005. 164: p. 1248-1257.
Conference and Symposia Presentations
M.Z., A. Shamloo, et al. MRI-guided epilepsy detection. in 2015 37th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society (EMBC). 2015. IEEE.
A., A. Shamloo, et al. An Enriched Finite Element Modeling for Metal
Forming Processes. in Proceedings of the
International MultiConference of Engineers and
Computer Scientists. 2008. Citeseer.
F., A. Shamloo, and N. Mehboudi. Dynamic
response of axonal microtubules under suddenly applied end forces. in 2014 36th Annual International Conference of the IEEE
Engineering in Medicine and Biology Society. 2014. IEEE.
A. Shamloo, M., et al. Thickness as
an important parameter in designing vascular grafts. in
Biomedical Engineering (ICBME), 2014 21th Iranian Conference on. 2014.
F. and A. Shamloo. Three dimensional modeling of axonal
microtubules. in Biomedical Engineering (ICBME),
2014 21th Iranian Conference on. 2014. IEEE.
Neuronal cell navigation within a microfluidic device. in
2nd Middle East Conference on Biomedical Engineering. 2014. IEEE.
E. GhafarZadeh, and A. Alasty.
Modeling and simulation of crossing magnetic nanoparticles through Blood
Brain Barrier (BBB). in 2014 36th Annual
International Conference of the IEEE Engineering in Medicine and Biology
Society. 2014. IEEE.
M.Z., A. Shamloo, et al. Steered Molecular Dynamic Simulation
Approaches for computing the Blood Brain Barrier (BBB) Diffusion
Coefficient. in World Congress on Medical Physics
and Biomedical Engineering, June 7-12, 2015, Toronto, Canada. 2015.
A, Heilshorn SC.
Microfluidic Platforms for Study of 3D Cell Chemotaxis within Biomaterials.
MRS Fall Meeting,
MA, December 2011.
Shamloo A, Nguyen CH, Manchandia
MD, Weinberg K, Heilshorn SC. Paradoxical
and chemorepellent effects of Kit ligand (KL)
revealed in novel microfluidic
Society of Hematology conference, Orlando, FL, December 2010.
Shamloo A, Heilshorn
SC. The interplay between biomechanical and biochemical factors regulates
formation and navigation of endothelial cell sprouts, ASME summer
Naples, FL, June 2010.
Shamloo A, Heilshorn SC. A three-dimensional micro-environment for characterizing
sprouting, Society for Biomaterials, Seattle, WA, April
Shamloo A, Heilshorn SC. Microfluidic models of endothelial cell sprouting in response to
biomechanical and biochemical Microenvironments, AVS
Symposium, San Jose, CA, Nov 2009.
A, Heilshorn SC. Matrix rigidity mediates growth factor response
during 3D endothelial
cell sprouting, 2009 Joint ASCE-ASME-SES
Conference on Mechanics and Materials, Blacksburg,
VA, June 2009.
A, Khoei. AR, Application
of extended finite element method (XFEM) in double-surface
model, 1st National Congress on
Civil Engineering (NCCE), Tehran, Iran, May 2004.
Shamloo A, Heilshorn
SC. Novel receptor –mediated endothelial cell chemotaxis, Biophysical
San Francisco, CA, Feb. 2010.
A, Heilshorn SC.
Concentration gradient generation for mammalian cell culture using a novel
device. Nanotech 2008 -
11th Annual NSTI Nanotechnology, Boston, MA, June 2008.
A, Heilshorn SC. A
shear-free microfluidic device for mammalian cell chemotaxis. Bio-X
Initiatives, Stanford, CA, Feb 2008.
A, Heilshorn SC. A novel
microfluidic device for endothelial cell chemotaxis. Cardiovascular
Retreat, Stanford, CA, Feb 2008.
AR, Shamloo A, Anahid
M, Shahim K, The extended finite element method
problems, 11th International
Conference on Metal Forming, Birmingham, UK, Sep
A, Azami AR, Khoei AR, Modeling of pressure-sensitive materials
using a cap plasticity
theory in extended
finite element method, International
Conference on Advances in Materials and
Processing Technologies (AMPT), Gliwice, Poland,
AR, Shamloo A, Implementation of
extended finite element method in pressure-sensitive
material using cap
plasticity model, 3rd
International Conference on Advances in Structural
Engineering and Mechanics (ASEM), Seoul, Korea,